I have seen many people stating that they have the same problem.

I have the font DPI setting set to 125% normal size (from the Display
Properties dialog when you right-click on the Desktop). If a Windows
Form is more than simle (has many controls), then the most chance is
that when the Form is shown in runtime, the layout is somewhat in right
condition (Some controls might position beyond the visible client area).

I am not sure if Microsoft noticed this problem. I think it is a very
*BAD* problem, based on that Microsoft/Windows have been strong in user
friendly GUI since their beginning.

My $0.02.